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Thanks to a first-of-its-kind platform, we are starting to understand how the molecular engine responsible for transcription in mammals controls its speed. A team of researchers from The Rockefeller ...

Cells are the basic building blocks of life—the smallest units that can do all the jobs a living thing needs. Most cells fit into two groups: prokaryotes and eukaryotes. The most significant ...

In eukaryotic cells, present in animals, plants, fungi and protists, most DNA is concentrated in the nucleus. This membrane-bound organelle serves as the command center of the cell, protecting the ...

An international collaboration between four senior scientists from Mainz, Valencia, Madrid, and Zurich has published groundbreaking research in the journal PNAS, shedding light on the most significant ...

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Eukaryotic cells, however, tend to have more potential opportunities for gene regulation: for example, it’s also common for eukaryotes to have gene regulation that is post-transcription but before ...

DNA transcription by RNA Polymerase twists and supercoils the DNA. The resulting DNA torque mechanically restraints Polymerase motion, playing a regulatory role in transcription elongation. While this ...

Yeast is a single cell eukaryotic organism, that incites in this Irish scientist an intense memory of the smell of brewing Guinness, wafting down the River Liffey on a drizzly Dublin day as I sit at ...

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A promoter is a DNA sequence fragment located upstream of a structural gene. It can activate RNA polymerase to precisely bind to template DNA and has the specificity of transcription initiation. In ...