For decades, scientists have known that motor proteins like kinesin-2 ferry vital cargo along microtubule "highways" inside cells. But how these molecular vehicles identify and bind to the right cargo ...

Summary: Researchers have identified a previously unknown “hook-like” domain in the tail of the kinesin-2 motor protein that explains how these molecular machines select the right cargo inside cells.

The kinesin-2 motor protein uses a hook-like adaptor and cargo-binding (HAC) domain to recognize and transport cargo along microtubule highways, revealing a cellular logistics system critical for ...

Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, Leiden, Netherlands Late endosomes/lysosomes (LE/Lys) and lysosome related organelles (LROs) move ...

Version of Record: This is the final version of the article. This manuscript investigates the role of the neck linker in coordinating the stepping cycles of the two heads of a kinesin-1 motor.

A team of researchers from Tohoku University, the National Center of Neurology and Psychiatry, and National Yang Ming Chiao Tung University has uncovered a novel molecular mechanism through which ...

Abstract: Mechanical stress on cells is transmitted through many biological processes, for example, cell shape control, tissue patterning, and axonal homeostasis. Microtubules, a cytoskeletal ...

Most of us will probably be able to recall at least vaguely that a molecule called ATP is essential for making our bodies move, but this molecule is only a small part of a much larger system. Although ...