News Medical

Scientists map kinesin-2 tail structure to understand cargo binding

For decades, scientists have known that motor proteins like kinesin-2 ferry vital cargo along microtubule "highways" inside cells. But how these molecular vehicles identify and bind to the right cargo ...
Neuroscience News

New Study Uncovers the Structural Key to How Cells Ship Cargo

Summary: Researchers have identified a previously unknown “hook-like” domain in the tail of the kinesin-2 motor protein that explains how these molecular machines select the right cargo inside cells.
Frontiers

Glycogen synthase kinase 3β (GSK3β) and presenilin (PS) are key regulators of kinesin-1-mediated cargo motility within axons

1 Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, United States 2 Department of Biological Sciences, The State University of ...
The EMBO Journal

A structural model for monastrol inhibition of dimeric kinesin Eg5

Eg5 or KSP is a homotetrameric Kinesin‐5 involved in centrosome separation and assembly of the bipolar mitotic spindle. Analytical gel filtration of purified protein and cryo‐electron microscopy (cryo ...
Live Science

What is the Standard Model, the subatomic physics theory that has been tested more than any other?

The Standard Model is the modern physical understanding of three of the four forces of nature: electromagnetism, the strong nuclear force and the weak nuclear force. When you purchase through links on ...
eLife

Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 –tubulin complex

Our editorial process produces two outputs: (i) public reviews designed to be posted alongside the preprint for the benefit of readers; (ii) feedback on the manuscript for the authors, including ...
Frontiers

Kinesins in Mammalian Spermatogenesis and Germ Cell Transport

In mammalian testes, the apical cytoplasm of each Sertoli cell holds up to several dozens of germ cells, especially spermatids that are transported up and down the seminiferous epithelium. The ...
C&EN

Multiscale Coarse-Grained Model for the Stepping of Molecular Motors with Application to Kinesin

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...
Brandeis University

Liquids that can move on their own

Assistant professor of physics Guillaume Duclos calls it the "swirl." It's made up of two types of cellular proteins -- kinesin and microtubules -- interacting to create a vortex under the microscope.
PNAS

Structural consequences of hereditary spastic paraplegia disease-related mutations in kinesin

Motor proteins are important biological machines responsible for cellular transport. Malfunctioning of them causes several neurodegenerative diseases. We searched for a molecular-level answer for ...
Labroots

Kinesin - A Critical Transport Protein

Learn more about an important cellular protein called kinesin from this video by the University of California San Francisco (UCSF), and Ron Vale Ph.D., a UCSF researcher. Kinesin is a motor protein, ...