Chemists created an enzyme with boronic acid at its reactive center. This approach can produce more selective reactions with boron, and allows the use of directed evolution to improve its catalytic ...

Small self-cleaving ribozymes catalyse the same reversible phosphodiester-cleavage reaction, but can adopt different structures and use distinct catalytic strategies. These catalytic RNAs do not ...

Timothy J. Wilson, Nan-Sheng Li, Jun Lu, John K. Frederiksen, Joseph A. Piccirilli, David M. J. Lilley, Olke C. Uhlenbeck Proceedings of the National Academy of ...

Using a clever chemogenetic suppression analysis, the authors provide compelling evidence that an RNA enzyme uses general acid catalysis. Their approach, which merges chemical substitution with enzyme ...

Scientists at the University of Groningen turned a non-enzymatic protein into a new, artificial enzyme by adding two abiological catalytic components: an unnatural amino acid and a catalytic copper ...

University of Groningen chemists have created a new enzyme with an unnatural amino acid as its active centre. They made the enzyme by modifying an antibiotic binding protein which normally acts as a ...

A new study published in the journal Nature Catalysis on February 10, 2020, reports the creation of a new artificial enzyme from two components, both non-biological in origin. This event marks the ...

Bifunctional acid−base catalysts are highly desirable for industrially relevant chemical processes. Owing to their ability to activate electrophiles and nucleophiles simultaneously, they allow the ...

Enzymology is the study of enzymes and enzyme-catalyzed reactions. Enzymes are biological catalysts that accelerate the rate of biological reactions. They can also perform multiple reactions ...

Although many organisms respond to light, very few enzymes inside those organisms use light directly as an energy source for catalysis. Researchers now report a new light-driven enzyme: Christened ...

A research team describes how they engineered an efficient new enzyme that can produce a synthetic genetic material called threose nucleic acid. The ability to synthesize artificial chains of TNA, ...