Nanovials are emerging as an accessible platform for performing single-cell functional screening leveraging standard instrumentation, such as flow cytometers and microfluidic single-cell sequencing ...

T cells are vital for surveillance within the immune system. They are activated once the T cell receptor (TCR) binds its cognate peptide found in cell surface proteins encoded by the major ...

Cancer immunotherapy approaches such as adoptive transfer of chimeric antigen receptor (CAR) T cells or tumor-infiltrating lymphocytes have yielded promising results in hematological malignancies.

A promising breakthrough in autoimmune disease research may open the door to safer and more effective treatments. Scientists have engineered a special antibody that can selectively calm the immune ...

To enhance CAR T therapies, scientists are actively studying TCR signaling and T-cell exhaustion mechanisms to improve CAR T persistence and function. Additionally, there is a growing trend towards ...

According to one of the authors, additional work is needed to validate findings in a larger prospective study ‘and to apply ...

Immune checkpoint inhibitors, popularized by Allison and Honjo’s Nobel Prize, were one of the first cancer immunotherapies that gained FDA approval. In the 1990s, Allison and Honjo identified the ...

An engineered protein turns off the kind of immune cells most likely to damage tissue as part of Type-1 diabetes, hepatitis, multiple sclerosis, shows a new study in mice. In these autoimmune diseases ...

Discover how T-cell receptor clonotype biomarkers help identify high-risk MF/SS patients, improving risk stratification and ...