An international collaboration steered by David Cortez, Richard N. Armstrong, Ph.D. Chair for Innovation in Biochemistry, explored how cells tolerate DNA damage and genome instability—and they arrived ...
The complete and accurate replication of the genome is essential to maintain genome integrity. Replication forks face many obstacles that can result in replication fork stalling or replication fork ...
Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids
Transcription-replication collisions (TRCs) are crucial determinants of genome instability. R-loops were linked to head-on TRCs and proposed to obstruct replication fork progression. The underlying ...
Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...
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