(HealthDay)—A group of metabolites whose levels decline as people age appear to have an effect on the circadian clock, according to a study published online Oct. 8 in Cell Metabolism. Ziv Zwighaft, ...

The polyamines are present in virtually all cells, prokaryotic or eukaryotic. Their biosynthesis and metabolism are highly regulated and unique active cellular transporters exist. They are known to be ...

The intestine is among the most regenerative tissues in the body; however, aging triggers various changes that collectively diminish its regenerative capacity. Consequently, the intestine becomes more ...

Monoclonal antibodies (mAbs) are laboratory-designed proteins that mimic the immune system's antibodies. To date, many therapeutic mAbs belonging to the immunoglobulin G (IgG) class of antibodies, ...

A breakthrough discovery reveals how the SLC45A4 gene fine-tunes polyamine transport in sensory neurons, reshaping our understanding of pain and opening new paths for targeted therapies. Study: ...

A phase 0/Ia study of BI 907828 concentrations in brain tissue and a nonrandomized, open-label, dose escalation study of BI 907828 in combination with radiotherapy in patients with newly diagnosed ...

Polyamines, the nitrogen-packed aliphatic molecules produced by our own cells and found in the foods we eat, have been cast by some as anti-aging dynamos. Studies suggest the compounds, most notably ...

Polyamines are small organic compounds that play a role in such fundamental cellular processes like cell division and growth. Consequently, polyamine deficiency can have negative impacts on health, ...

With aging, the intestine gradually loses its ability to regenerate after damage. An international research team involving the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena and ...

There is no shortage of advice on what to eat after one receives a diagnosis of cancer. The possibility that dietary interventions could enhance cancer treatment outcomes has generated considerable ...