In a recent study published in the IUBMB journal, researchers assessed the association between platelet-activating factor (PAF) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ...

Platelet-Activating Factor (PAF) is a bioactive phospholipid that orchestrates diverse events in vascular homeostasis and inflammation. Synthesised rapidly in response to cellular stimuli, PAF engages ...

Platelet-Activating Factor (PAF) is a potent glycerophosphocholine lipid mediator with central roles in physiological homeostasis and pathological inflammation. Synthesised via both a de novo pathway ...

The contractile responses of esophageal smooth muscle (SM) induced by platelet-activating factor (PAF) involve the activation of L-type voltage-dependent calcium channels (L-type VDCCs), ...

Researchers from Miguel Hernández University of Elche (UMH) in Spain have identified an effective strategy to reduce structural liver damage and improve hepatic vascular function in cirrhosis. The ...

PAF causes strong contractions—especially in the muscles of the esophagus and the stomach’s upper region (called the gastric fundus). In other parts of the intestine, such as the small intestine and ...

Heparin-induced thrombocytopenia (HIT) is an immune-mediated platelet disorder caused by antibodies that target complexes of platelet factor 4 (PF4) and heparin. HIT has been characterized as a ...

Background Janus kinase inhibitors (JAKis) are emerging therapies for SLE, but concerns regarding thromboembolic risk persist ...

A research group has uncovered important details about how platelet-activating factor (PAF)—a powerful molecule involved in inflammation and allergic reactions—triggers contractions in the smooth ...