Researchers have discovered how newly created neurons depend on blood flow in the adult brain to travel from their site of origin to their final location. The study in mice, published today in eLife ...

Migrating newborn neurons suffer routine double-strand DNA breaks from physical stress during brain development.

Radial neuronal migration is a critical process for the formation of the cerebral cortical layers. Although transcriptional regulators are implicated in neuronal migration, the molecular mechanisms ...

During brain development, neurons can regulate their movement until they reach their final destination thanks to a "molecular switch" involving the protein Teneurin 4 (Ten4). This protein can guide ...

Using microfluidic devices mimicking the crowded spaces in the developing brain, researchers gained novel insights into distinct modes of locomotion found in neurons. In the developing brain, neurons ...

Disruptions in neuronal migration or cortical lamination can lead to profound alterations in cortical circuitry, impairing synaptic connectivity and information processing—defects linked to a range of ...

Doublecortin is a neuronal microtubule-associated protein that regulates microtubule structure in neurons. Mutations in Doublecortin cause lissencephaly and subcortical band heterotopia by impairing ...

As newborn neurons make their way through the developing brain, they must squeeze through incredibly tight spaces to reach their final destinations. Researchers discovered that this physical journey ...

An illustration of zebrafish heart development, showing the migration of cells in the growing embryo after 17 hours, 1 day and 2 days to form the heart. Most heart cells come from the embryonic ...