A pair of studies examining immune response in C. elegans reveal broad implications for understanding pathogen detection in higher animals and the evolutionary origins of immunity itself. The research ...

Scientists in the laboratory of Weiguo Cui, Ph.D., professor of Pathology in the Division of Experimental Pathology, have identified novel molecular mechanisms that help specialized T-cells maintain ...

A mechanism of antiviral immunity in bacteria has been characterized. A research team from Umeå University (Sweden) has uncovered a mechanism for how bacteria build up antiviral immunity against ...

Researchers found a molecular mechanism, shared in cancer and pregnancy, that suppresses the immune system. Block this mechanism, called B7-H4, and the immune system revs up to slow cancer's growth.

New imaging reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. Germinal centers are high-speed evolution ...

In chronic hepatitis B, the liver contains immune cells that could destroy hepatitis B virus infected cells but are inactive. A team from the Technical University of Munich (TUM) has discovered that ...

Obesity alters bone health not only through increased body weight but also by reshaping the bone marrow environment. Researchers show that expansion of bone marrow fat promotes immunosuppressive PD-L1 ...

In the 1880's and 1890's, Robert Koch established that a different microbe causes each infectious disease. Koch defined a process by which a specific causative organism could be identified by ...

This figure illustrates the synergistic pathways by which Tregs establish immune tolerance, which are essential for preventing allograft rejection. Key mechanisms include: (1) the direct suppression ...

Mammalian immunity has long been thought to rely solely on proteins and specialized immune cells. However, a newly proposed concept—RNA immunity—is reshaping this perspective. In a recent publication ...