New study shows that targeting an oft-drugged family of cell membrane receptors with biased modulators can expand potential drug targets and reduce side effects.
Rat hepatocytes in monolayer culture rapidly internalized asialoglycoproteins and the receptors to which they are bound. Subsequent to endocytosis, the receptor-ligand complex is dissociated within an ...
Just as a home security system can alert a homeowner to the presence of an intruder, a protein called polyglutamine binding protein-1 (PQBP1) found in brain cells can alert the body to the presence of ...
Mammalian odorant receptors are a diverse and rapidly evolving set of G protein-coupled receptors expressed in olfactory cilia membranes. Most odorant receptors show little to no cell surface ...
New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...
Bitter taste receptors inside cancer cells have been found to be activated in the presence of anti-cancer drugs. Shutting ...
Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.
Chemists discovered how the epidermal growth factor receptor changes its shape when it binds to its target, and how those changes trigger cells to grow and proliferate. Receptors found on cell ...
Besides inducing “trips,” psychedelics such as LSD—administered in parallel to psychological support—have been shown to have beneficial effects in cases of depression, anxiety, and addiction. Although ...
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