Inflammation immunology has emerged as a central field for understanding the balance between host defense and pathological immune activation.

Dozens of new discoveries reveal that defenses evolved by bacteria and viruses billions of years ago still define our own innate immune system. Evolutionary arms races — where one species is pitted ...

The innate immune system employs inflammasomes—intracellular multiprotein platforms—to detect microbial motifs and danger signals, triggering rapid inflammatory responses. Upon sensing perturbations ...