In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists have recently identified the mechanism behind regulated splicing of large constitutive exons which ...

Neoantigen screening identifies EGFR L858R mutation immunogenicity in 1862 Chinese NSCLC patients. Using real-world data to investigate time-dependent blood count response to PD-1 and PD-L1 inhibitors ...

Alternative splicing (AS) is a key technique for increasing transcriptome and proteomic diversity from a small genome. Almost all human gene transcripts are alternatively spliced, resulting in protein ...

In TDP-43 proteinopathies, the RNA/DNA binding protein leaves its post in the nucleus and travels to cytosol, where it’s prone to aggregate. This meandering allows mis-spliced transcripts to ...

In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists from Nagoya University, Japan, led by Associate Professor Akio Masuda, have recently identified the ...