If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

Escherichia coli replicates its genome through a finely tuned ensemble of proteins that assemble at the replication fork to form the replisome. Central to this machinery are the DNA polymerase III ...

New findings suggest the end-replication problem, an old standby of biology textbooks, is twice as intricate as once thought. Half a century ago, scientists Jim Watson and Alexey Olovnikov ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment has been the focus of a 30-year research question. New work from the Crick ...

We have gone further than ever before in creating life that is unlike anything that has evolved naturally. The genome of an Escherichia coli bacterium has been redesigned on a computer to use just 57 ...