DNA mismatch repair (MMR) is a fundamental pathway that maintains genomic integrity by recognising and correcting errors introduced during DNA replication and recombination. In prokaryotes, the ...

A new study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...