Human DNA constantly refolds in 3D space, and these looping dynamics regulate gene expression and cell identity.

For decades, scientists viewed the genome of a newly fertilized egg as a structural "blank slate"—a disordered tangle of DNA ...

Getting DNA into a living cell sounds simple, until you remember the cell’s outer membrane acts like a guarded wall. DNA ...

Researchers developed Pico-C to map genome folding in early embryos, uncovering a prebuilt 3D scaffold before gene activation ...

New findings show that the genome’s 3D structure is constantly changing, with NIPBL guiding loop formation that regulates active genes. Faulty folding dynamics may underlie cancers and developmental ...

Researchers from Tokyo Metropolitan University have created a new molecule which carries DNA into biological cells, to treat or vaccinate against illnesses. Many existing options rely on molecules ...

Alan Herbert, Founder and President of InsideOutBio, discusses the evolution of biological concepts related to DNA and protein structures ...

For many years, researchers believed that the DNA inside a newly fertilized egg began as a structural ‘blank slate’ – a loose ...

New work from UC Davis and the University of Utah shows how the 3D structure of DNA inside a germ cell commits it to develop into a sperm cell. The discovery could improve understanding of fertility ...

The human genome has to be carefully organized so it will fit inside of the nuclei of cells, while also remaining accessible to the cellular machinery that works to express the right genes at the ...

Different DNA Structures Nucleate the Folding of Proteins to form specific complexes that modulate the readout of ...